Wellbutrin XL (Bupropion Hydrochloride XL)

Wellbutrin XL (Bupropion Hydrochloride XL)

Bupropion Hydrochloride XL

Product information

Wellbutrin XL (bupropion hydrochloride extended-release) is a medication used for the treatment of major depressive disorder (MDD) and seasonal affective disorder (SAD).

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Product strength & quantity


Product strength & quantity


Product strength & quantity


Product strength & quantity


Wellbutrin XL (Bupropion Hydrochloride)

  • Antidepressant, specifically a norepinephrine-dopamine reuptake inhibitor (NDRI).


  • Used for the treatment of major depressive disorder (MDD).
  • Used for the prevention of seasonal affective disorder (SAD).

Dosage Forms

  • Available in extended-release tablets of various strengths (e.g., 150 mg, 300 mg).


  • Taken orally, typically once a day in the morning.
  • Tablets should be swallowed whole, not crushed, divided, or chewed.


  • Varies based on individual needs and medical conditions.
  • Usually starts with a lower dose, may be increased gradually.

Side Effects

  • Common: Dry mouth, headache, nausea, insomnia, sweating.
  • Serious: Seizures, high blood pressure, severe allergic reactions, mood changes (e.g., agitation, hallucinations).


  • Not recommended for individuals with seizure disorders or those allergic to bupropion.
  • Use caution in patients with a history of bipolar disorder.
  • Avoid abrupt discontinuation of the medication.


  • Can interact with MAO inhibitors, other antidepressants, certain antipsychotics, theophylline, and systemic steroids.
  • Alcohol and CNS depressants may increase risk of adverse effects.

Pregnancy and Lactation

  • Use only if potential benefit justifies potential risk to the fetus.
  • Bupropion passes into breast milk; weigh risks and benefits.


  • Store at room temperature, away from moisture and heat.
  • Keep out of reach of children.