Janumet (Sitagliptin/Metformin Hydrochloride) Tablets

Janumet is a combination medication containing Sitagliptin and Metformin Hydrochloride, designed to improve blood sugar control in adults with Type 2 diabetes. Sitagliptin, a DPP-4 inhibitor, enhances the body’s natural insulin release, while Metformin decreases glucose production in the liver. Together, they offer a powerful solution for managing blood sugar levels when diet and exercise alone are insufficient.

Key Information:

• Form: Oral tablet, taken by mouth.
• Strengths: Available in 500mg/50mg and 850mg/50mg tablets (Metformin/Sitagliptin).
• Indications: Type 2 diabetes management.
• Dosing: Typically taken twice daily, with meals.

Mechanism of Action

Janumet combines two mechanisms to effectively lower blood sugar levels:

• Sitagliptin: Inhibits the enzyme DPP-4, increasing incretin levels to promote insulin production and reduce glucose release from the liver.
• Metformin: Decreases glucose production in the liver and improves insulin sensitivity, enhancing glucose uptake by muscles.

Uses of Janumet

• Type 2 Diabetes Management: Janumet helps improve glycemic control when used with diet and exercise.
• Combination Therapy: May be prescribed alongside other diabetes medications for enhanced blood sugar control.

Common and Serious Side Effects

• Common Side Effects: Nausea, diarrhea, stomach upset, and headache.
• Serious Side Effects: Lactic acidosis (a rare but serious condition), low blood sugar (when used with other diabetes medications), and kidney problems. Seek medical attention if you experience symptoms like muscle pain, breathing difficulty, or unusual tiredness.

How to Take Janumet

• Dosage: Janumet is usually taken twice daily with meals to reduce stomach upset and improve absorption.
• Administration: Swallow tablets whole with water. Do not crush or chew them.

Patient Guidelines

• Inform your healthcare provider of any history of kidney or liver problems, or if you are pregnant or breastfeeding.
• Continue to monitor your blood sugar levels regularly as directed by your doctor.
• Avoid excessive alcohol consumption to reduce the risk of lactic acidosis.

Where to Store Janumet

Store Janumet tablets at room temperature (68°F to 77°F or 20°C to 25°C) in a dry place. Keep the tablets in their original container and protect them from moisture and heat. Keep out of reach of children and pets. Do not use expired medication, and dispose of unused tablets safely.

Effectiveness and Reliability

Janumet has been clinically proven to effectively lower blood sugar levels in adults with Type 2 diabetes. Its dual mechanism of action and combination of two trusted diabetes medications make it a reliable option for long-term diabetes management.

Common Issues and Troubleshooting

• If you miss a dose, take it as soon as you remember unless it’s close to your next dose. Do not double up on doses.
• Monitor for symptoms of low blood sugar, such as sweating, dizziness, or shaking, especially when used with other diabetes medications.
• Contact your healthcare provider immediately if you experience unusual symptoms such as muscle pain or severe abdominal discomfort.

References

• WebMD - Janumet Overview
• Healthline - Janumet Uses and Side Effects
• Drugs.com - Janumet Information

Your healthcare provider will prescribe Janumet (500mg/50mg or 850mg/50mg) to be taken twice daily with meals. Swallow the tablets whole with water to reduce stomach upset and improve effectiveness. Store Janumet at room temperature and keep it in its original container to protect it from moisture. Monitor your blood sugar regularly and report any unusual symptoms such as muscle pain or severe nausea to your doctor promptly.